Clonal diversity of CML patients across disease stages. Clonal evolution models per sample stage based on our mutation pattern model. Paired circles indicate separate inferred subclones, with the smaller circle always representing Ph⁻ clones. Dotted lines indicate clones that were successfully treated and remain only in low levels (pattern 3 at follow-up denotes the 2 different clonal scenarios). Boxes on the right are colored to indicate TKI response per patient.