Candidate compound-related epigenetic changes at distinct histone H3 methylation sites around the CD19 promoter. (A-B) Relative levels of H3K9me3 (A) and H3K27me3 (B) in the CD19 promoter regions P1-P5 of compound 49–exposed L428 cells, detected by ChIP, normalized to the untreated control (UT). (C-D) Relative levels (as in panels A and B) of H3K9me3 (C) and H3K4me3 (D) in compound 40–exposed L1236 cells. Cells were treated with each compound at 10 μM for 48 hours. Data are presented as mean ± SD; *P < .05.