Distribution of 378 genomic events identified by mate-pair sequencing in 11 cases of PTCL, NOS. (A) Number of genomic events per case. (B-D) Representative Circos diagrams illustrating heterogeneity in the degree of complexity of genomic events among PTCLs: (B) high complexity; (C) focally high complexity with multiple rearrangements involving chromosomes 16 and 19 (chromothripsis); and (D) low complexity. (E) Distribution of intrachromosomal and interchromosomal events. (F) Distribution of events based on involvement of genes or nongenic regions and identification of expression fusion transcripts by RNA sequencing.