Percentage of patients meeting proposed Major Criteria who responded to therapy in the siltuximab study, based on number of proposed Minor Criteria. n represents total number of patients treated with at least that number of Minor Criteria and ≥1 laboratory abnormality. Using Fisher’s exact test, those who met ≥2 Minor Criteria were significantly more likely to respond to siltuximab than those who did not meet 2 Minor Criteria (P = .0003).