Microarray analysis of colon ECs reveals profound metabolic and cytoskeletal changes during initiation of angiogenesis in GVHD. (A) Hierarchical clustering of microarray data from colon ECs from ALLO and SYN mice at day+2 after BMT (LP/J→C57BL/6) (n = 4 per group). Red and blue represent high and low levels of gene expression, respectively. (B) Selected pathways with involved genes being differentially expressed in ECs between ALLO and SYN mice. In supplemental Tables 1 and 2, a detailed list of gene symbols + names, fold changes, and P values is available. (C) Volcano plot for the expression of total genes (34 472 genes). Red and blue crosses represent 145 upregulated and 99 downregulated genes, respectively. (Fold Change [linear] < −2 or >2, analysis of variance P value (Condition pair) < .05).