Platelets partially restore pathogenesis to eCM-protected CD40-KO mice. (A) Clinical scores, (B) percent survival, and (C) parasitemia for groups (n = 5) CD40-KO reconstituted with WT platelets (filled green square), CD40-KO injected with saline (open blue square), or C57BL/6 controls (filled red triangle). Gray shaded area indicates the time period for the development of neurologic symptoms by C57BL/6 mice. Values are average ± SEM. *P < .05 for comparison of CD40-KO + platelets groups with other 2 groups; #P < .05 for comparison of C57BL/6 with other 2 groups.