Tissue tolerance is context dependent. (Line a) A linear relationship by health and immune burden regulated by tissue tolerance. (Line b) Another linear relationship, but one where tissue tolerance may appear to be greater or less than (line a) depending on measurement conditions. (Line c) A nonlinear mode of tissue tolerance–mediated regulation of health where tissue tolerance may appear relatively high or low depending on measurement conditions. Adapted from Little et al⁵¹  with permission.