Figure 4.
Figure 4. Engraftment of HSCs in unconditioned bone marrow, in which SCF is deleted from CAR cells. The numbers of donor (CD45.2+), endogenous (CD45.1+CD45.2+), and total phenotypic HSCs (CD34−CD150+CD48−LSK) in untransplanted mice, and in control and Lepr-Cre;SCFf/f unconditioned recipients 16 weeks after the transplantation of 1.6 × 108 purified Lin− cells (n = 4). All error bars represent standard deviations of the means. *P < .05; **P < .01.

Engraftment of HSCs in unconditioned bone marrow, in which SCF is deleted from CAR cells. The numbers of donor (CD45.2+), endogenous (CD45.1+CD45.2+), and total phenotypic HSCs (CD34−CD150+CD48−LSK) in untransplanted mice, and in control and Lepr-Cre;SCFf/f unconditioned recipients 16 weeks after the transplantation of 1.6 × 108 purified Lin− cells (n = 4). All error bars represent standard deviations of the means. *P < .05; **P < .01.

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