Mouse models: key milestones and timeline. A schematic of publication dates and the disease phenotype for different model systems. Green, expression from the endogenous locus; red, viral transduction models; blue, stable transgene models. MLL-AF9 models: 1996,²⁶  2000,³⁰  2005,³² 2006,^33,34  2007,⁴⁰ 2008,⁴¹ 2013,³⁶ 2015,⁴²  2016.³⁸  MLL-ENL models: 1997,⁴³  2003,^31,35,45  2005,³²  2007,⁴⁰  2009,¹¹  2012,⁴⁸  2014,⁵⁰ 2015.⁴²  MLL-AF4 models: 2006,^27,52  2008,⁵⁴  2010,⁸  2011,^56,60  2016.⁶⁵  OHT, 4-hydroxytamoxifen; Ras, rat sarcoma mutation; t-ALL, T-cell acute lymphoblastic leukemia.