PFS of patients with iMCD after treatment with different therapies. (A) Among all iMCD patients, siltuximab was not correlated with PFS when compared with rituximab or rituximab-based therapy significantly, although a trend toward better survival is suggested. (B) There was no significant difference in PFS between treatment with siltuximab and treatment with chemotherapy or corticosteroids. (C) There was no significant difference in PFS between treatment with rituximab or rituximab-based therapy and chemotherapy or corticosteroids. (D) Rituximab or rituximab-based therapy was correlated with better PFS in patients with HIV-positive and HHV-8–positive MCD compared with iMCD.^9,32,33  Chemo and Cor, chemotherapy or therapy with corticosteroids only; R and R-based, rituximab or rituximab-based therapy.