PFS of patients with non-TAFRO iMCD and overall survival of patients with and without TAFRO. (A) Treatment with siltuximab led to better PFS than rituximab or rituximab-based therapy. (B) Rituximab or rituximab-based therapy and chemotherapy or corticosteroids had similar PFS. (C) Treatment with siltuximab was correlated with better PFS than treatment with chemotherapy or corticosteroids. (D) In all patients, TAFRO syndrome correlated with significantly poorer patient survival. Chemo and Cor, chemotherapy or therapy with corticosteroids only; OS, overall survival; R and R-based, rituximab or rituximab-based therapy.