Virological responses to cidofovir and brincidofovir and relationship between complete responses and lymphocyte reconstitution in the 2 groups. (A-B) Shows kinetics of adenoviremia after treatment with cidofovir and brincidofovir, respectively. Viral load (log10 copies/mL) are plotted on the y-axis and days after HCT are plotted on the x-axis. Cidofovir mediated major virological responses (2-log reduction in 2 weeks) in 2 of 23 episodes. In contrast, 13 of 18 episodes demonstrated major virological responses with brincidofovir (P < .0001). The majority of responses to brincidofovir were major. Minor responses (1-log reduction in 2 weeks) were observed only in 2 episodes. Brincidofovir mediated CR in 13 patients (80%) and cidofovir mediated CR in 8 patients (35%) (P < .01). (C) Compares the lymphocyte count at the resolution of viremia following treatment with brincidofovir (n = 15) and cidofovir (n = 8). The median lymphocyte count at the resoluton of viremia after brincidofovir vs cidofovir was 320/μL vs 910/μL, respectively. The resolution of viremia occurred in the brincidofovir group despite significant lymphopenia of >300/μL. In contrast, resolution of viremia occurred in the cidofovir group when lymphocyte count was >300/μL (P < .05). ADV, adenovirus; BCV, brincidofovir; CDV, cidofovir, CR, complete response.
