GATA factor mechanistic principles. (A) GATA switch model. GATA switches involve replacement of one GATA factor by another at a chromatin target site. GATA switches can be associated with an altered transcriptional output. The GATA switch is illustrated at the Gata2 locus. In erythroblasts, friend of GATA-1 (FOG-1) promotes GATA-1-mediated replacement of chromatin-bound GATA-2, instigating repression.^64,74  (B) Coregulator dependency matrix model. “Sensitive” and “insensitive” denote whether reductions in the endogenous coregulators impact expression of the GATA-1 target genes. Distinct coregulator ensembles mediate GATA-1-dependent transcription in a locus-specific and context-dependent manner.^91,98,99,173