GATA-2 mutations in human hematologic disorders inform GATA factor mechanisms. (A) Left, GATA-2 N-finger mutations in human AML patients with biallelic CEBPA mutations.^{160-163,174,175}  V296 corresponds to GATA-1 V205, which enhances GATA-1 and FOG-1 binding. Right, C-finger mutations identified in AML-associated diseases.^{153-156,158,176-178}  T354M is a loss-of-function mutation that inhibits chromatin occupancy and target gene activation.^122,123  L359V was identified in chronic myeloid leukemia.¹⁵⁹  (B) Mutations at and near the +9.5 GATA switch site enhancer in pediatric MDS¹⁶⁹  and MonoMAC syndrome.^35,157,158  del, deletion; ins, insertion.