DCs inhibit TRALI-associated physiological responses. (A-D) Rectal temperatures (A), MIP-2 levels (B), pulmonary PMN percentages (C), and lung MPO enzyme activity (D) of either naive WT C57BL/6 mice or CD11c-DTR mice that were injected (+) or not (−) with the indicated reagents or antibodies. All mice were analyzed 90 minutes after the second injection. For the statistical analyses, only significant comparisons of interest are shown. The comparisons shown in panels A,C-D were analyzed by a 1-way ANOVA with a Tukey’s post hoc test. Each dot represents 1 mouse, and error bars represent SD. *P < .05, ****P < .0001.