An activated mature neutrophil presenting a cognate antigen to a memory CD4 T cell in a MHC-II–dependent fashion, which, in turn, proliferates, becomes activated, and produces cytokines (IL-2, IFNγ, and TNFα). Likely, costimulator molecules (CD40, CD80, and CD86) play a role in this process. Presumably, CD4 T-cell–derived cytokines activate the neutrophil, whereas neutrophil-derived mediators (cytokines) activate the CD4 T cell.