Compared with control mice, RBC^HIGHmice have a shortened TTO. (A-D) Control and RBC^HIGH mice were subjected to FeCl₃-induced carotid artery thrombosis. (A) TTO. When vessels did not occlude, time to occlusion was recorded as 20 minutes (3 control mice). (B) Onset and (C) rate of thrombus formation in control (uninfused) and RBC^HIGH mice. (D) Control and RBC^HIGH mice were treated with saline (baseline) or heparin and then subjected to tail transection. Each dot or box is a separate mouse; boxes with asterisks represent mice that did not form clots. Lines indicate median values, Wilcoxon 1-tailed comparison.