CBL mutations and currently published mouse models of mutant Cbl. (A) Protein domains of CBL with location of mutation hotspots in the linker and RING domain regions of the protein. In red are the recurrently mutated amino acid residues in myeloid neoplasms, with the Q367P mutation highlighted. (B) Published mouse models of Cbl mutations, including the newly described Cbl^Q367P/Q367P model by Nakata et al.