Effects of gene mutations on overall survival after stem cell transplantation. (A) Overall survival and incidence of relapse in patients carrying different numbers of genetic abnormalities, which are shown in indicated colors. Hazard ratios according to numbers of genetic events are provided. (B) Volcano plot of hazard ratios (in horizontal axis) and corresponding P values (in vertical axis) according to univariate analysis of the effect of individual genetic and clinical factors on overall survival. Size of circles corresponds to the fraction of patients carrying indicated factors, among which significant (P < .05) ones are annotated. Clinical, cytogenetic, and genetic factors are shown in green, blue, and red, respectively. (C) Relative contribution of clinical and genetic factors to the log hazard of overall survival in Cox proportional hazards regression modeling. Contribution of both combined and individual factors are depicted in horizontal and vertical axis, respectively. (D) Effects of the number of genetic factors, as indicated by color, on overall survival are shown in Kaplan-Meier curves. Hazard ratios relative to zero genetic factor are presented. One case with 4 genetic factors was incorporated in cases with 3. CKcg, CK by conventional cytogenetics; CK-like, CK by sequencing analysis; Dx, diagnosis; HR, hazard ratio; HSCT, hematopoietic stem cell transplantation; PLT, platelet; PS, performance status; Ref/Rel, refractory or relapse.