Effects of genetic risk on survival within IPSS-defined risk groups. Kaplan-Meier curves for patients with (red) and without (blue) genetic risk are depicted for each IPSS-defined risk group: (A) low; (B) Int-1; (C) Int-2; (D) high. Cases whose initial diagnosis was MDS/MPN were excluded from the analysis. Genetic risk factors included TP53, NRAS, and CBL mutations and CK. Patients carrying 1 or more of the 4 genetic lesions were defined as cases with genetic risk.