Effects of TP53 and CK on survival and relapse. (A-B) Effects of TP53 mutation and CK as determined by conventional cytogenetics (CKcg), sequencing-based analysis (CK-like), and combined assays as indicated by color. (C) Effects of TP53 mutation and CK on overall survival in the external cohort. Overall survivals (A,C) and cumulative incidence of relapse (B) for the patients with indicated abnormalities are shown in each panel. The numbers of patients at risk are shown at indicated time points along the bottom (A,C). Hazard ratios are also indicated in corresponding colors with 95% confidence intervals.