Effects of RAS-pathway mutations on overall survival. (A) Effects of combined RAS-pathway mutations on overall survival. Kaplan-Meier curves for individual RAS-pathway mutations, including NRAS, KRAS, CBL, NF1, and PTPN11 genes are also presented in indicated colors. (B) Effects of RAS-pathway mutations depending on disease subtype. (C) Effects of RAS-pathway mutations for sAML subtype depending on initial diagnosis. Kaplan-Meier curves for disease subtypes (B) and initial diagnosis (C) are presented. The numbers of patients at risk are shown at indicated time points along the bottom (A-C). Hazard ratios are also indicated in corresponding colors with 95% confidence intervals.