American Society of Hematology

Figure 2.

$Figure 2. Analysis of HSPC numbers and detection of activated signaling pathways. (A) Comparison of cell numbers of whole, stem, and progenitor fractions in the control and CblQ367P BM. (B) Activation of ERK, AKT, STAT3, and STAT5 proteins in the HSC subpopulations. Representative photos taken with a confocal microscope and relative fluorescent intensities to those of control LT-HSCs are shown in the left and right panels, respectively. Scale bar: 10 μm. ***P < .001; **P < .01, *P < .05. ns, not significant.$

Analysis of HSPC numbers and detection of activated signaling pathways. (A) Comparison of cell numbers of whole, stem, and progenitor fractions in the control and Cbl^Q367P BM. (B) Activation of ERK, AKT, STAT3, and STAT5 proteins in the HSC subpopulations. Representative photos taken with a confocal microscope and relative fluorescent intensities to those of control LT-HSCs are shown in the left and right panels, respectively. Scale bar: 10 μm. ***P < .001; **P < .01, *P < .05. ns, not significant.

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