![A cell belonging to a subtype of AML clusters which is characterized by high cytoplasmic nucleoside kinase activity (deoxycytidine kinase [DCK], CMPK1, and NME) is depicted. As a consequence, a large nucleoside pool is imported in mitochondria via the SLC25A33/36 and SLC29A3 import carriers as indicated by the green boxes on the left of the mitochondrial membrane. This pool favors mtDNA biosynthesis, oxidative phosphorylation (OXPHOS), and increased oxygen consumption rate (OCR). ddC treatment minimizes mtDNA content upon its activation in 2′,3′-dideoxycytidine triphosphate (ddCTP) (on the right) and import into mitochondria. This treatment allows the tumor regression in a mouse model. POLG2, DNA polymerase γ2.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/129/19/10.1182_blood-2017-03-773200/4/blood773200f1.jpeg?Expires=1735519155&Signature=OYd-z2o8O2oiRzplL1B5YAbmIFX5RdbpNEyLZjGCNoGbY3NSL8njID8KE~LN1QEZxB82CE7HtILHPISIVtGMPA7VQQTeD-PoxSrr5GvL9NFdrqckXiWM9fJ~BdmdQTCwhywZp-b-C4boCxPrdezgVQi2nE05IQ~I~8z1RAdvWlSpSD9d7lyuMPq8H0O-hmsa1B7m2~IXsiUFcj-v2R9VHyqk2a9LcsaPm-LX05zfJda8LbvDxHlwF6i59SdOC~xK~k7kXi~xa1HM9OIoHKWXPiblrs9m1URff~LLX9-~0j4q029vzBRrCK4f8Rw7u~SFB6Qdb6UVZUCwt1XzGuHTkw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
A cell belonging to a subtype of AML clusters which is characterized by high cytoplasmic nucleoside kinase activity (deoxycytidine kinase [DCK], CMPK1, and NME) is depicted. As a consequence, a large nucleoside pool is imported in mitochondria via the SLC25A33/36 and SLC29A3 import carriers as indicated by the green boxes on the left of the mitochondrial membrane. This pool favors mtDNA biosynthesis, oxidative phosphorylation (OXPHOS), and increased oxygen consumption rate (OCR). ddC treatment minimizes mtDNA content upon its activation in 2′,3′-dideoxycytidine triphosphate (ddCTP) (on the right) and import into mitochondria. This treatment allows the tumor regression in a mouse model. POLG2, DNA polymerase γ2.
