Example of a PET-driven strategy (GAINED trial). The GAINED trial compares Obinutuzumab (GA-101) vs Rituximab (R) plus chemotherapy (CHOP or ACVBP according to local practice) for untreated IPI 2-3 DLBCL patients younger than 60 years. PETs are performed at diagnosis, after 2 and 4 cycles of chemotherapy. iPET response is analyzed according to the ΔSUVmax method. Patients with an early good response receive the scheduled immunochemotherapy according to initial randomization (either CHOP or methotrexate [MTX]/vépéside [VP]-Ifosfamide/Aracytine [Arac]), slow responders (as defined by a ΔSUVmax: iPET2 < 66% and iPET4 > 70%) receive 2 courses of high-dose methotrexate followed by ASCT, whereas nonresponders (as defined by a ΔSUVmax: iPET2 < 66% and iPET4 < 70%) receive a salvage therapy according to local investigators. All iPET are centrally reviewed, and patient’s treatments are based on central review. The study is closed for inclusion and enrolled 671 patients. BEAM, BCNU, etoposide, cytarabine, melphalan.