Model of a novel role for platelet DREAM. Megakaryocyte DREAM mRNA and protein are transferred to platelets during thrombopoiesis. In platelets, DREAM regulates platelet activation by modulating PI3K-Iβ activity (for example, in GPVI-mediated signaling). ADP signaling further activates αIIbβ3 integrin and amplifies integrin outside-in signaling which also activates PI3K-Iβ through DREAM.