Figure 5.
![Figure 5. Binding of 2,3-DPG to Hb. (A-B) 2,3-DPG binds in the cleft between the β (yellow) subunits of the T quaternary structure. (C) Reduction of 2,3-DPG concentration shifts the quaternary equilibrium toward R to produce a left shift in the binding curve and increases the solubility (the concentration of Hb in the solution phase [Figures 3B and 4B, left]). Both factors decrease sickling.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/129/20/10.1182_blood-2017-02-765891/4/blood765891f5.jpeg?Expires=1735828703&Signature=qgTI702gp8GqNt-pSG8ZLKQNXuTExbrIl~14MgTRuL42AoAyto8a07mvoP9qNsJDcSXJ3vTWWu9GWV~5S-oAxEtzpbaky4RsVkC0IgkVcMlbMfDGrOXZBK9cAgRyfyuEXNbsfgTDAEeNhXpVmfXuwyV2p8DJJFwEYL4NkQxbBDduHvfNhl~xgoVFHL22HuTW8gtnnE2H3orf-L53swC5upJy0SczM8FNKZoOLAZySyswGr46MEN31hFFWX9zg8aAMUKlPLpoiYBfHOSy-yWNAqWRv4KF~Eg-fcv82SsgMSrUzaRIBaQ56nKa6PNtt2BL03wGv5vqUerUo0Sz9CRZ6w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Binding of 2,3-DPG to Hb. (A-B) 2,3-DPG binds in the cleft between the β (yellow) subunits of the T quaternary structure. (C) Reduction of 2,3-DPG concentration shifts the quaternary equilibrium toward R to produce a left shift in the binding curve and increases the solubility (the concentration of Hb in the solution phase [Figures 3B and 4B, left]). Both factors decrease sickling.
