Classical inhibitory function of ITIM-containing receptors. The inhibition of ITAM-containing receptor signaling through the recruitment of the Src homology 2 (SH2) domain-containing protein-tyrosine phosphatases Shp1 and Shp2, or SH2 domain-containing inositol 5’-phosphatase 1 Ship1. Btk, Bruton's tyrosine kinase; DAG, diacylglycerol; ER, endoplasmic reticulum; IP₃-R, inositol trisphosphate receptor; P, phosphate; PI3-K, phosphoinositide 3-kinase. Professional illustration by Patrick Lane, ScEYEnce Studios.