Platelet ITIM-containing receptors. The main structural features are shown, including the extracellular IgC₂-like and IgV-like domains and the main intracellular signaling motifs, namely ITIMs (consensus sequence I/V/LxYxxL/V), ITSMs (consensus sequence TxYxxV/I), and PRRs (consensus sequence PxxP) along with nonconsensus ITIM/ITSM-like tyrosine residues. All receptors have been described in platelets except for LAIR-1, which is only found in megakaryocytes. Residues are numbered according to mature mouse peptide sequences, after cleavage of the signal peptide. Professional illustration by Patrick Lane, ScEYEnce Studios.