Classical and putative functions of ITIM-containing receptors. Increasing evidence is implicating ITIM-containing receptors as more than just inhibitors of ITAM-containing receptors, particularly as positive regulators of integrin-mediated functions. Their potential role in both regulating cytoskeletal remodeling and G protein–coupled receptor (GPCR) signaling warrants additional investigation. Professional illustration by Patrick Lane, ScEYEnce Studios.