Cardiac and renal involvement according to immunoglobulin variable region gene usage. Other κ/λ: includes rare κ genes (KV2-28, 30, 38, KV3-01, 07,11, KV6-21, rare KV1 excluded); rare λ genes (LV1-01, 36, 52, 57, LV2-08, 11, 18, LV3-09, 10, 20, 25, LV4-60, 69, and LV10-54); cases where only family could be determined (n = 39); and cases that no gene or family could be determined (n = 77); KV1-other: includes rare KV1-genes (KV1-02, 06, 08, 09,12, 13, 17 and 27). P = nonsignificant across groups within patients with cardiac involvement. P < .0001 across gene groups within patients with renal involvement. C, cardiac; R, renal.