OxLDL induces activation of redox sensor ERK5 in a CD36-dependent manner. Platelet ERK5 activation was detected in washed human platelets (3 × 10⁸/mL) (A) after stimulation with varying doses of oxLDL for 15 minutes, (B) after the time course stimulation with oxLDL (top) or native LDL (bottom) (50 µg/mL), (C) after the treatment with CD36 blocking antibody FA6 or control IgG antibody (1 µg/mL) (n = 3), and (D) after stimulation with other CD36 ligands, the prothrombotic S100A protein family member MRP14 (1 µg/mL), and TSR (0.35 µg/mL) (n > 4). Significance was determined by 2-tailed Student t test (C) and 1-way ANOVA with Dunnett post hoc analysis (A,D). Data represented as mean ± SEM.