Myeloid progenitors isolated from AML mice display partial HSC signature and largely maintain MEP identity. RNA-Seq–based gene expression comparison between control myeloid progenitors (Ctrl-MP) and myeloid progenitors isolated from AML mice (AML-MP). (A) Heat map depicting relative expression of HSC signature (genes DE in long-term HSCs [LT-HSCs] vs MPPs, previously described³³ ) in AML MPs. Genes in blocks a1 and a2 show similar expression profiles between AML MPs and LT-HSCs. (B) Heat map showing relative expression of MEP signature (genes differentially expressed in MEPs vs LSKs, CMPs, and GMPs, previously described³⁴ ) in Ctrl- and AML-MPs. Genes in blocks b1 and b2 demonstrate similar expression profiles between AML-MPs and MEPs. (C) Expression levels of Gata1 and Gata2 in Ctrl- and AML-MPs were quantified using reads per kilobase of transcript per million mapped reads (RPKM). (D) Venn diagram illustrating the overlap among DE genes in AML-MPs and DE genes in Gata2−77^−/− CMPs (Gata2).