Figure 3.
NPM-ALK achieves most of the “Hallmarks of Cancer.” NPM-ALK is the protein product of a chromosomal translocation. Through activation of T-cell signaling pathways and dysregulation of the phosphoproteome, NPM-ALK drives the transformation of T cells into ALK+ ALCL by multiple oncogenic mechanisms. Diagram modified from Hanahan and Weinberg.73 (*) According to Lai and Ingham.74
