Unrelated donor-recipient pairs have more genome-wide recipient mismatching than sibling pairs. For each coding SNP, recipient mismatching was counted as 0 or 1, where a value of 0 indicates no recipient mismatching and a value of 1 indicates mismatching for 1 or both alleles. The extent of genome-wide mismatching for each recipient was calculated as the proportion of SNPs with mismatching. Histograms show the numbers of patients for each 0.001 increment of genome-wide recipient mismatching for coding SNPs among full-sibling recipients (red, left-side peak) (N = 1840) and unrelated recipients (blue, right-side peak) (N = 1217). Light green dots show the day-100 cumulative incidence of grades III-IV acute GVHD within deciles across the respective ranges of genome-wide recipient mismatching in sibling and unrelated recipients.