Associations of signaling nodes and overall survival in MCL. (A) Identification of the basal- and activation-induced signaling nodes with largest variance across MCL samples. (B) For all individual signaling nodes above a variance threshold set to 0.025, the patients were divided into 2 groups, with measurements greater than or less than the cohorts median value, and association with patient overall survival were tested with the log-rank test. Shown are histograms of P values using log-rank test or Cox regression analysis of the same variable. (C) Distribution of the sum of the 5 significant basal levels as determined by Cox regression (p-AKT, p-ERK, p-STAT1, p-STAT5, and p-p38) across MCL patients. (D) Kaplan-Meier analysis of overall survival, based on the 3 groups identified in panel C (n = 42; P < .0032).