Stat1 KO mice exhibit no significant population shifts with antibiotic therapy. (A) Total LSK and (B) granulocytes from bone marrow were quantified by flow cytometry for WT, Stat1 KO (Stat1^−/−), Nod2 KO (Nod2^−/−), and MyD88 KO (MyD88^−/−) with (+) and without (0) antibiotic therapy (VNAM). Results are pooled from 2 to 4 independent experiments (n = 4-25 per group per analysis). The graphs show mean + SEM, statistical significance was determined by Student t test. ns, not significant; *P < .05, **P < .01, ***P < .001. (C) Proposed model of antibiotic-associated bone marrow suppression.