Figure 1.
Mutation numbers and spectrum within the FL discovery sample set. Baseline genomic features of FL are shown for the exome sequenced discovery cohort. Clinical features (upper) are indicated for all 28 samples sequenced from 24 individuals. Immediately below the clinical features is a row indicating the total number of mutations per sample. Mutations per megabase sequenced (middle) is based on the total mutations within the targeted exome capture space successfully covered in each sample (80% breadth, 20× depth), with the percentage of the sequenced target region covered in each sample indicated immediately below in green. Finally, the rate of transitions and transversions in the mutations observed in each individual are shown (bottom). Bulk fresh-frozen samples were sequenced unless indicated (*) as a flow-sorted sample. Brackets group multiple samples from a single individual. MB, megabase; Ti, transition; Tv, transversion