Frequencies of mutations affecting the BCR/CXCR4 signaling pathways and SWI/SNF complex in patients with FL. (A) The interconnected BCR and CXCR4 signaling pathways are shown. Genes with nonsynonymous coding or splice site mutations are depicted in green, with SMGs in dark green and the mutation frequency observed in the entire cohort (N = 105) indicated. The total number and types of mutations observed are shown in the inset bar graph. (B) Recurrent mutations affecting both BAF (BRG1-associated factor) and PBAF (polybromo BRG1-associated factor) SWI/SNF complexes were observed in our cohort and annotated as in A. See supplemental Table 11 for a complete list of mutations. *Frequency includes 2 ARID1A variants rescued after ESP filtering.