Age distribution of cytopenias and donor CHIP. (A) Donor age in HSCT recipients with >95% chimerism after day 100 based on the presence of persistent cytopenias with (explained) and without (unexplained) identified cause. Box limits indicate the 25th and 75th percentiles, whiskers extend to the 10th and 90th percentiles, and dots represent outliers. (B) Donor age distribution among patients with cytopenias. Donor age is plotted on a single axis, with the white portion representing age <40 years and the black portion representing age 40 years and older (overall range, 15-72 years). Patients who underwent next-generation sequencing as part of their evaluation are represented by circles (red, donor CHIP; blue, no donor CHIP). Patients who did not undergo sequencing are represented by hatch marks.