rADAMTS13 enhances neovascularization during stroke recovery. (A) Quantification of BrdU⁺/CD31⁺ endothelial cells in WT mice treated with vehicle or rADAMTS13 at 14 days after stroke. (B) Representative images and quantification of IB4⁺ endothelial tip cells in WT mice treated with vehicle or rADAMTS13. Bar = 25 μm. (C) Quantification of vascular branches in WT mice treated with vehicle or rADAMTS13. (D) Representative images of CD31⁺ microvessels in WT mice treated with vehicle or rADAMTS13, and quantification of CD31⁺ microvascular length and percent area occupied by vascular structures for each group. Scale bar = 100 μm. (E) Representative images of tomato-lectin–perfused vessels and quantification of lectin-perfused vessel area in WT mice treated with vehicle or rADAMTS13. Scale bar = 200 μm. Values are mean ± SD. Unpaired, 2-tailed Student t test. n = 6 per group, *P < .05.