The central role of P2Y12 receptor in platelet-induced cancer cell proliferation. Cho et al demonstrate that platelet-induced proliferation and growth of ovarian cancer cells requires platelet activation mediated by ADP-P2Y12 signaling. The use of the P2Y12 antagonist ticagrelor may be a useful therapeutic approach to limit ovarian cancer growth. AC, adenylyl cyclase; Gi, inhibitory regulative G-protein; PI3K, phosphatidylinositol 3-kinase. Professional illustration by Patrick Lane, ScEYEnce Studios.