Molecular relapses and TFR after 2G-TKI discontinuation. (A) Evolution of BCR-ABL1 transcripts over time as measured by RT-qPCR from 2G-TKI discontinuation until MMR loss in relapsing patients (n = 26). Red lines correspond to molecular relapses occurring within 12 months after treatment cessation, and blue lines to relapses occurring after 12 months. (B) Cumulative incidence of molecular relapses. (C) Treatment-free remission.