miRNAs play context-dependent roles in AML. A model for context-dependent effects of a specific miRNA given different transcriptional backgrounds between 2 distinct AML-driver mutations, mutation A and mutation B. Mutation A leads to the transcription of mRNA A, B, and C, whereas mutation B drives the transcription of mRNA X, Y, and Z. All mRNAs have predicted targeting by the example miRNA. The miRNA depicted in mutation A and mutation B is the same hypothetical miRNA.