Figure 1.
![Figure 1. NF-kB pathway. Immune receptor signaling pathways leading to NF-κB activation can be grouped into 4 categories on the basis of the surface receptors involved: developmental receptors (receptor activator of NF-κB, vascular endothelial growth factor receptor-3, and ectodysplasin-A receptor), antigen receptors (T-cell receptor [TCR] and B-cell receptor [BCR]), members of the TNF receptor superfamily (TNF-Rs: tumor necrosis factor receptors, CD40, FAS, etc), and members of the Toll-interleukin receptors superfamily (TIR: IL-1 receptors and TLRs). The protein of the NF-kB signaling pathway (NEMO) responsible for EDA-ID is shown in black.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/130/12/10.1182_blood-2017-03-771600/4/blood771600f1.jpeg?Expires=1735805527&Signature=CwFTP-t~9ZjmPup4ASNkOL1Zgj3Lim4juFrlaAu7~qeVyhGABUhr~AdeePi8uC2iDtQJJgMJjfRLBweOsiYegcTaW4onfhXNm0dy9Kzft0D3dBsAg1ZsYIsF~9GNNXpE0UFtdG9V8MTISZLgj-YjmlFdh1bzIMLyOFk9u3OxwGcyj2ejyPio8~ysTWp1MUJFlYkdqcjwFXTpXVVKu2Mo7VSxzJ44CTKqdvGX2BaoONnBpErOfLRFTqa7yCndctYHu~cEYACpr6BwH7nxuheQDpARsR-XqdyVrYIMfPq19MkZsuR1ZwH4x56W9BYRRLooN1FMMeNaibyKxbv7F5sfFw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
NF-kB pathway. Immune receptor signaling pathways leading to NF-κB activation can be grouped into 4 categories on the basis of the surface receptors involved: developmental receptors (receptor activator of NF-κB, vascular endothelial growth factor receptor-3, and ectodysplasin-A receptor), antigen receptors (T-cell receptor [TCR] and B-cell receptor [BCR]), members of the TNF receptor superfamily (TNF-Rs: tumor necrosis factor receptors, CD40, FAS, etc), and members of the Toll-interleukin receptors superfamily (TIR: IL-1 receptors and TLRs). The protein of the NF-kB signaling pathway (NEMO) responsible for EDA-ID is shown in black.
