Schematic of mutations in recurrently mutated signaling pathways in CTCL. CTCL harbors recurrent mutations that are predicted to affect (A) chromatin, (B) T-cell activation/NF-κB signaling, (C) JAK/STAT signaling, and (D) MAPK signaling. Putative oncogenes and tumor suppressor genes are indicated in red and blue boxes, respectively. Frequencies of single nucleotide variant and copy number variants are indicated as percentages in left and right boxes under the genes, respectively. Prevalence of copy number mutations were obtained from a previous study.9 Point mutations and copy number amplifications in putative oncogenes are red. Point mutations and copy number deletions in putative tumor suppressors are blue. Darker hues indicate higher frequency of mutation. SNV, single nucleotide variant; CNV, copy number variant.
