Figure 4.
Figure 4. BM features of LGL leukemia. (A) Hematoxylin and eosin staining (HES) of marrow biopsy reveals a slightly hypercellular marrow with a subtle increase in interstitial lymphocytes. (B) CD3 staining reveals the LGL interstitial infiltration. (C) Immunoperoxydase staining for CD8 demonstrates clusters of at least 8 cytotoxic lymphocytes CD8+. (D) Linear array of intravascular LGL demonstrated by Granzyme B (GzB) staining. (E) CD57 staining reveals the LGL interstitial infiltration. Original magnifications ×4 (A), ×40 (B), ×20 (C), ×100 (D), and ×20 (E). Images courtesy of Philippe Gaulard (Department of Pathology, Henri Mondor Hospital, Assistance Publique–Hôpitaux de Paris, Creteil, France) and Patrick Tas (Department of Pathology, Rennes University Hospital, Rennes, France).

BM features of LGL leukemia. (A) Hematoxylin and eosin staining (HES) of marrow biopsy reveals a slightly hypercellular marrow with a subtle increase in interstitial lymphocytes. (B) CD3 staining reveals the LGL interstitial infiltration. (C) Immunoperoxydase staining for CD8 demonstrates clusters of at least 8 cytotoxic lymphocytes CD8+. (D) Linear array of intravascular LGL demonstrated by Granzyme B (GzB) staining. (E) CD57 staining reveals the LGL interstitial infiltration. Original magnifications ×4 (A), ×40 (B), ×20 (C), ×100 (D), and ×20 (E). Images courtesy of Philippe Gaulard (Department of Pathology, Henri Mondor Hospital, Assistance Publique–Hôpitaux de Paris, Creteil, France) and Patrick Tas (Department of Pathology, Rennes University Hospital, Rennes, France).

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