Activated PC rescues defective insulin signaling in DKD. (A-D) DKD in insulin-resistant db/db mice without (saline) or with various interventions. Representative immunoblots (A) and bar graphs (B-C) showing nuclear levels of ER transcription factors in renal cortex samples. Dot plot summarizing albuminuria (D). db/m, control mice without diabetes; aPC+HAPC¹⁵⁷³, aPC preincubated with the monoclonal HAPC¹⁵⁷³ antibody. Mean ± SEM of at least 6 (B-C) or 8 (D) mice per group. *P < .05; **P < .01 (B-D: ANOVA).