Validation attempts of previously reported significant candidate gene-association studies in DISCOVeRY-BMT at least twice. Survival association P values as reported in previous literature (A) and validation attempts of these associations in DISCOVeRY-BMT cohort (B) are shown as data points. Horizontal panels indicate the genes that these 17 polymorphisms are located in or closest to as reported by the previous studies. Shapes represent associations with survival outcomes DRM, OS, PFS, and TRM; colors correspond to donor, recipient, or donor-recipient mismatch polymorphisms. The size of the point represents the sample size of the study, with larger points reflecting a bigger sample size. Shown on x-axis are the 17 polymorphisms from the literature reporting associations at P < .05 with OS, PFS, or TRM by 1 or more previously published studies; the y-axis is the −log₁₀ (P value). The red horizontal lines in (A) and (B) indicate P = .05. Details on the haplotypes are described in “Results” under “Validation.”