Figure 2.
Analysis of relevant immunophenotypic compartments in 27 adult patients with BCR-ABL1–positive BCP-ALL using FISH after FACS. (A) BCR-ABL1 positivity of immunophenotypic compartments in the 2 predominant patterns of BCR-ABL1 occurrence. The green and orange color content of the boxes represents the ratios of BCR-ABL1 fusion–positive and –negative signal constellations observed in the 27 patients. For details of sorting strategies, see supplemental Data. (B) Detailed results of the analysis for each patient and compartment. Green, BCR-ABL1 fusion negative; orange, BCR-ABL1 positive; gray, not analyzable. Overall, 11 of 27 patients showed an MPP pattern, 13 of 27 showed a B-lineage pattern, and 3 of 27 had a pattern between the two (indeterminable [i.d.]). M, major BCR-ABL1 transcript; m, minor BCR-ABL1 transcript; mM, minor and major BCR-ABL1 transcripts identified; n.a., not analyzable.